Fenbendazole capsules are a broad spectrum benzimidazole anthelmintic used for the control of gastrointestinal parasites in dogs, cats, horses, sheep, fish (including freshwater shrimp tanks), rabbits and a number of exotic species. It also has anti-inflammatory effects and is effective against liver flukes in pigs. It is also used under veterinary to control giardia in humans.
In dogs, fenbendazole is labeled for removal of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala), whipworms (Trichuris suis), and tapeworms (the Taenia genus; not effective against Dipylidium caninum, a common dog tapeworm). It is also approved to remove lungworms (Metastrongylus apri and Metastrongylus pudendotectus) in cattle, big cats such as lions and leopards (Fundulus helvetica), and pinworms in nonlactating goats and in a variety of other domestic and exotic animals. It has also been found to be effective in removing hepatocellular carcinoma tumors in humans and was recently reported to improve a patient’s survival when combined with radiation therapy in cancer patients.
In animal studies, fenbendazole has been shown to reduce the growth of experimental tumors by blocking cell proliferation and inhibiting mitotic spindles, and by inducing apoptosis through direct interaction with microtubules. In a murine model, fenbendazole has also been shown to have anti-inflammatory and anti-inflammatory properties and to be a potent inhibitor of cell migration. fenbendazole capsules